Preferred Label : Ivabradine Hydrochloride;
NCIt synonyms : (7,8-Dimethoxy 3-(3-(((1S)-(4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one
Hydrochloride; 2H-3-Benzazepin-2-one, 3-(3-((((7S)-3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-,
Monohydrochloride; Ivabradine HCl;
NCIt definition : The hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated,
cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity.
Upon administration, ivabradine selectively binds to the intracellular portion of
the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial
(SA) node. This inhibits the If (funny) pacemaker ion current, prevents the inward
flow and intracellular accumulation of positively charged ions, reduces pacemaker
activity and slows diastolic depolarization. This decreases heart rate, reduces myocardial
oxygen demand and allows more time for blood to flow to the myocardium without affecting
cardiac contractility. HCN channels, mixed sodium (Na ) and potassium (K ) channels
that carry the inward If current, play a key role in the regulation of pacemaker firing
rate in the SA node. The If pacemaker current, the inward flow of positively charged
Na -K ions, initiates the spontaneous diastolic depolarization phase and modulating
heart rate.;
UNII : TP19837BZK;
InChIKey : HLUKNZUABFFNQS-ZMBIFBSDSA-N;
CAS number : 148849-67-6;
Drug name : Corlanor;
NCI Metathesaurus CUI : CL551119;
Origin ID : C148546;
UMLS CUI : C1685365;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
