Preferred Label : Anti-CD3/MUC1 Antibody-armed PD-1 Inhibitor-induced Cytokine-induced Killer Cells;
NCIt synonyms : PD-1 Activated CIK Armed With Anti-CD3/Anti-MUC1 Bispecific Antibody; Anti-CD3/MUC1-armed PD-1 Inhibitor-induced CIK Cells;
NCIt definition : A preparation of cytokine-induced killer cells (CIKs), which have been exposed, ex
vivo, to a specific set of cytokines and a programmed cell death protein 1 (PD-1)
inhibitor, mixed with a bispecific anti-cluster of differentiation 3 (CD3)/anti-mucin-1
(MUC1) antibody, with potential anti-tumor cytotoxic activity. Upon administration
of the anti-CD3/MUC1 antibody-armed PD-1 inhibitor-induced CIKs, the antibody moiety
binds to both CD3 on the CIKs and MUC1 on cancer cells. This crosslinks the CIKs and
tumor cells, which allows the CIKs to target and lyse MUC1-expressing cancer cells.
PD-1 blockade activates the CIKs. The cytokines used, usually interferon-gamma (IFNg),
interleukin 1 (IL-1), and IL-2, stimulate the proliferation and maturation of peripheral
blood mononuclear cells (PBMCs) into CIK cells. Anti-CD3 stimulation allows for the
CIKs' improved lytic activity.;
NCI Metathesaurus CUI : CL551126;
Origin ID : C148543;
UMLS CUI : C4725117;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
