Preferred Label : Polyinosinic-polycytidylic Acid/Inactivated Rabies Virus Vaccine YS-ON-001;
NCIt synonyms : Poly IC/Inactivated RV-V YS-ON-001;
NCIt definition : A cancer vaccine composed of inactivated rabies vaccine (RV-V) and polyinosinic-polycytidylic
acid (poly IC; poly I-C), an immunostimulant and Toll-like receptor 3 (TLR3) agonist,
with potential immunostimulating and antineoplastic activities. Upon administration
of the poly IC/inactivated RV-V YS-ON-001, the RV-V stimulates the immune system in
various ways, such as promoting the activation and proliferation of T helper type
1 (Th1) cells, dendritic cells (DCs), B cells and natural killer cells (NKs), promoting
macrophage M1 polarization, downregulating regulatory T-cells (Tregs), and inducing
the production of anti-tumor cytokines. This re-activates immune responses in the
suppressed tumor microenvironment (TME), leading to an induction of cytotoxic T-lymphocyte
(CTL)-mediated immune response against the tumor cells, which cause tumor cell apoptosis
and a reduction of tumor cell proliferation. Poly IC, a synthetic double-stranded
RNA with one strand composed of a inosinic acid polymer and the other strand a cytidylic
acid polymer, binds to TLR3 and stimulates the release of cytotoxic cytokines, such
as interferon-gamma (IFNg). This may boost the immune response against the tumor cells.;
Molecule name : YS ON 001; YS-ON-001;
NCI Metathesaurus CUI : CL551131;
Origin ID : C148534;
UMLS CUI : C4725108;
Semantic type(s)
- concept_is_in_subset
