Preferred Label : Amdizalisib;
NCIt synonyms : PI3K-d Inhibitor HMPL 689; PI3K-delta Inhibitor HMPL 689;
NCIt definition : An orally bioavailable selective inhibitor of the delta isoform of phosphatidylinositide
3-kinase (phosphoinositide 3'-kinase delta; PI3Kd; PI3K-d), with potential antineoplastic
activity. Upon oral administration, amdizalisib selectively binds to and inhibits
PI3Kd, and prevents the activation of the PI3Kd/AKT signaling pathway, and B-cell
activation. This both decreases proliferation and induces cell death in PI3Kd-overexpressing
tumor cells. PI3Kd plays a key role in the B-cell receptor (BCR) signaling pathway
and the proliferation of hematologic cancer cells. The targeted inhibition of PI3Kd
is designed to preserve PI3K signaling in normal, non-neoplastic cells and thereby
to minimize serious side effects. PI3Kd, an enzyme often overexpressed in cancer cells,
plays a crucial role in tumor cell regulation and survival.;
UNII : F3YMY7783P;
CAS number : 1894229-05-0;
Molecule name : HMPL-689; HMPL 689;
NCI Metathesaurus CUI : CL551137;
Origin ID : C148532;
UMLS CUI : C5667167;
Semantic type(s)
- concept_is_in_subset
- has_target
