Preferred Label : Paclitaxel Polymeric Micelle Formulation NANT-008;
NCIt synonyms : Micellar Nanoparticle-encapsulated NANT-008; Nant-paclitaxel; Paclitaxel-loaded Micellar Diblock Copolymer NANT-008; Paclitaxel-loaded Polymeric Micelle NANT-008;
NCIt definition : A nanoparticle-based formulation consisting of polymeric micelles encapsulating the
taxane paclitaxel, with potential antineoplastic activity. Paclitaxel is covalently
bound to polyethylene glycol (PEG)-based block copolymers which forms a micellar structure
with an outer hydrophilic PEG shell surrounding the hydrophobic paclitaxel. Upon administration
of the paclitaxel polymeric micelle formulation NANT-008, the nanoparticles are stable
in the bloodstream and specifically accumulate in the tumor tissue. Due to the acidic
conditions in the tumor and the pH-responsive nature of the micelles, paclitaxel is
released in the tumor environment. Paclitaxel binds to microtubules, promotes microtubule
assembly, and prevents depolymerization, thus interfering with normal mitosis. Compared
to the administration of paclitaxel alone, this formulation increases the solubility
of paclitaxel, enhances its specific retention in cancer tissue, and increases its
therapeutic effect, while decreasing its toxicity. In addition, the micellar formulation
allows the delivery of higher doses of paclitaxel to target tissues while minimizing
systemic toxicity.;
Drug name : Cynviloq; Genexol-PM;
Molecule name : NANT-008; IG-001; NANT 008;
NCI Metathesaurus CUI : CL551138;
Origin ID : C148531;
UMLS CUI : C4724081;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
