Preferred Label : Amblyomin-X;
NCIt definition : A recombinant form of a toxic protein derived from the salivary glands of the Amblyomma
cajennense tick that inhibits Factor Xa and induces apoptosis, with potential antithrombotic
and antineoplastic activities. Upon administration, amblyomin-X promotes endoplasmic
reticulum (ER) stress, mitochondrial dysfunction, cytochrome-c release, poly(ADP-ribose)
polymerase (PARP) cleavage, and activation of caspase. Additionally, this agent selectively
induces apoptosis in tumor cells. It also affects endothelial cell functions, such
as adhesion, and may inhibit angiogenesis. Amblyomin-X targets and binds to factor
Xa, inhibits its activity and interrupts the blood coagulation cascade, thereby preventing
thrombin formation and thrombus development. As cancer is associated with thrombosis,
amblyomin-X could potentially exert its antineoplastic and antithrombotic effects
in the cancer patient at the same time.;
NCI Metathesaurus CUI : CL551143;
Origin ID : C148521;
UMLS CUI : C4725097;
Semantic type(s)
- concept_is_in_subset
