Preferred Label : EPS8 Peptide-specific Dendritic Cells;
NCIt synonyms : EPS8 Peptide-specific DCs;
NCIt definition : A preparation of dendritic cells (DCs) pulsed with peptides derived from epidermal
growth factor receptor (EGFR) pathway substrate 8 (EPS8), with potential immunostimulating
and antineoplastic activities. Upon administration of the EPS8 peptide-specific DCs,
the immune system is exposed to the EPS8 antigens. This results in the induction of
a specific cytotoxic T-lymphocyte (CTL) response against EPS8-expressing tumor cells
and tumor cell lysis. EPS8, a tumor-associated antigen (TAA), is overexpressed in
a variety of tumor cell types but rarely in normal tissues. As a substrate for the
EGFR kinase, it plays a key role in tumor progression through the EGFR-dependent pathway.
Its expression is correlated with a poor prognosis.;
NCI Metathesaurus CUI : CL551146;
Origin ID : C148518;
UMLS CUI : C4725094;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
