Preferred Label : ALK/c-Met Inhibitor TQ-B3139;
NCIt definition : An orally available, small molecule inhibitor of the receptor tyrosine kinases anaplastic
lymphoma kinase (ALK) and hepatocyte growth factor receptor (c-Met; HGFR), with potential
antineoplastic activity. Upon oral administration, TQ-B3139 binds to and inhibits
the activity of ALK and c-Met, which leads to the disruption of ALK- and c-Met-mediated
signaling and the inhibition of cell growth in ALK- and c-Met-expressing tumor cells.
ALK and c-Met, overexpressed or mutated in many tumor cell types, play key roles in
tumor cell proliferation, survival, invasion and metastasis.;
Molecule name : TQ-B3139; TQ B3139;
NCI Metathesaurus CUI : CL551150;
Origin ID : C148513;
UMLS CUI : C4725090;
Semantic type(s)
- concept_is_in_subset
