Preferred Label : Nanoparticle SN-38-encapsulated Micelle Formulation IT-141;
NCIt synonyms : Nanoparticle SN-38 Formulation IT141;
NCIt definition : A nanoparticle-based formulation consisting of polymeric micelles, composed of triblock
copolymers, loaded with the bioactive hydrophobic irinotecan metabolite 7-ethyl-10-hydroxy-camptothecin
(SN-38), with potential antineoplastic activity. Upon administration, nanoparticle
SN-38-encapsulated micelle formulation IT141 diffuses into the tumor site and the
SN-38 moiety binds to and inhibits topoisomerase I by stabilizing the cleavable complex
between topoisomerase I and DNA, which results in DNA breaks, inhibition of DNA replication,
and apoptosis. Compared to SN-38 alone, this formulation increases the water solubility
of SN-38 and allows the delivery of higher doses of SN-38. IT-141 also has a much
longer circulation time and reduces toxicity to normal, healthy tissues.;
Molecule name : IT-141;
NCI Metathesaurus CUI : CL551035;
Origin ID : C148511;
UMLS CUI : C4725088;
Semantic type(s)
- concept_is_in_subset
