Preferred Label : CDC7 Kinase Inhibitor LY3143921 Hydrate;
NCIt synonyms : LY-3143921 Hydrate; LY3143921 Hydrate;
NCIt definition : The hydrated form of an orally bioavailable inhibitor of cell division cycle 7 (CDC7)
kinase, with potential antineoplastic activity. Upon administration of CDC7 kinase
inhibitor LY3143921 hydrate, LY3143921 targets, binds to and inhibits the activity
of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction
of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing
tumor cells. The serine-threonine kinase CDC7 plays a key role in DNA replication
by binding to and phosphorylating serine (Ser)-40 and 53 of MCM2 (minichromosome maintenance
complex component 2), which is required for the initiation of DNA replication. Although
expressed at low levels in healthy, normal cells, CDC7 is expressed at much higher
levels in cancer cells.;
NCI Metathesaurus CUI : CL551033;
Origin ID : C148509;
UMLS CUI : C4725086;
Semantic type(s)
- concept_is_in_subset
