Preferred Label : Fluorine F 18-Al-NOTA-MATBBN;
NCIt synonyms : 18F-Al-NOTA-MATBBN;
NCIt definition : A radioconjugate containing a bombesin (BBN) peptide analog, derived from an unspecified
GRPR antagonist (MATBBN) that targets the gastrin-releasing peptide receptor (GRPR),
and is linked to the radionuclide fluorine F 18 (18F), by the macrocyclic chelating
agent, 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA), through a method that
first couples 18F to aluminum (Al), with potential use in diagnostic imaging using
positron emission tomography/computed tomography (PET/CT). Upon administration of
fluorine F 18-Al-NOTA-MATBBN, the peptide moiety targets and binds to GRPR. Upon PET/CT,
GRPR-expressing tumor cells can then be visualized. GRPR, also called bombesin receptor
2 (BB2), is a seven-transmembrane G protein-coupled receptor belonging to the bombesin
receptor family. It is overexpressed in certain types of cancers. Bombesin is a peptide
exhibiting high affinity for the gastrin-releasing peptide receptor (GRPR).;
NCI Metathesaurus CUI : CL551038;
Origin ID : C148508;
UMLS CUI : C4725085;
Semantic type(s)
- concept_is_in_subset
