Preferred Label : Anti-minor Histocompatibility Complex Donor T-Lymphocytes;
NCIt synonyms : MiHA-specific T Cells; MiHA T-lympocytes; GLIDE Cells; GLIDE T-lymphocytes; Anti-MiHA Donor T-lymphocytes; GLIDE; Anti-MiHA T Cells; Guided Lymphocyte Immunopeptide Derived Expansion Against MiHAs Cells; Guided Lymphocyte Immunopeptide Derived Expansion Cells;
NCIt definition : A preparation of allogeneic, donor-derived T-lymphocytes that are specific for a unique
set of minor histocompatibility complex antigens (MiHA) exclusively found on the surface
of malignant cells, with potential immunomodulating and antineoplastic activities.
T-lymphocytes are derived from an allogeneic hematopoietic cell transplant (AHCT)
donor. Ex vivo, these T-cells are exposed to and primed against a select set of host-specific
hematopoietic tissue-restricted MiHAs that are expressed on leukemic cells. Then the
cells are subsequently expanded. After AHCT and infusion of the anti-MiHA T-lymphocytes,
these cells target and bind to MiHA antigens expressed on the host's leukemia cells,
thereby killing these cancer cells. MiHA are small, cell-surface peptides that are
associated with graft-versus-host disease (GvHD). The selected set of MiHAs is expressed
mainly, or only, by hematopoietic cells, and overexpressed on leukemic cells.;
NCI Metathesaurus CUI : CL552436;
Origin ID : C148500;
UMLS CUI : C4724406;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
