Rubitecan - CISMeF

Preferred Label : Rubitecan;

NCIt synonyms : Nitrocamptothecin; 9-Nitro-20(S)-camptothecin; 9-nitrocamptothecin; 9-NC;

NCIt definition : A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. (NCI04);

Alternative definition : NCI-GLOSS: An alkaloid drug belonging to a class of anticancer agents called topoisomerase inhibitors.;

UNII : H19C446XXB;

InChIKey : VHXNKPBCCMUMSW-FQEVSTJZSA-N;

CAS number : 91421-42-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 91421-42-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Orathecin; Camptogen;

Molecule name : RFS 2000;

Chemical formula : C20H15N3O6;

NSC code : 603070;

Codes from synonyms : CDR0000045502;

Details

Origin ID

C1485;

UMLS CUI

C0213800;

Currated CISMeF NLP mapping
- rubitecan [MeSH concept]
- rubitecan [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- rubitecan [MeSH concept]
- rubitecan [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Etoposide/Nitrocamptothecin [NCIt concept]

Keyword's position in hierarchy(ies) :

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