Preferred Label : Carbon C 11-JNJ-63779586;
NCIt synonyms : 11C-JNJ-63779586;
NCIt definition : A radioconjugate composed of JNJ-63779586 labeled with the positron-emitting isotope
carbon C 11, with potential use in imaging via positron emission tomography (PET).
Upon administration of carbon C 11-JNJ-63779586, the JNJ-63779586 moiety acts as a
substrate for the efflux transporter P-glycoprotein (P-gp) and the breast cancer resistance
protein (BCRP). Upon PET imaging, this radioligand may allow for the assessment of
P-gp and BCRP function and expression in tumors. As P-gp and BCRP activity may influence
response to therapy, measuring P-gp and BCRP activity may be beneficial when choosing
chemotherapy. P-gp and BCRP, efflux transporters, are overexpressed by certain tumor
cells and may contribute to multidrug resistance to chemotherapy.;
NCI Metathesaurus CUI : CL551045;
Origin ID : C148497;
UMLS CUI : C4725080;
Semantic type(s)
- concept_is_in_subset
