Preferred Label : HER2-targeted DARPin MP0274;
NCIt synonyms : HER-2-targeting DARPin MP0274; HER2-targeting DARPin Drug MP0274; DARPin MP0274;
NCIt definition : A proprietary, designed ankyrin repeat proteins (DARPin)-based agent targeting the
tyrosine kinase receptor epidermal growth factor receptor 2 (HER2; ErbB2), with potential
antineoplastic activity. Compared to antibodies, DARPins are small in size, have favorable
pharmacokinetics and allow for both high affinity binding and efficacy. Upon administration,
the HER2-targeted DARPin MP0274 binds to two distinct non-overlapping epitopes on
HER2, thereby inhibiting the activity of HER2 and promoting HER2 internalization.
This prevents HER2-mediated signaling, induces apoptosis and inhibits the growth of
HER2-overexpressing tumor cells. DARPin also binds to human serum albumin, which extends
the half-life of MP0274. HER2 is overexpressed in a variety of cancer cell types and
is associated with increased tumor cell proliferation.;
Molecule name : MP 0274; MP0274;
NCI Metathesaurus CUI : CL551054;
Origin ID : C148491;
UMLS CUI : C4725074;
Semantic type(s)
- concept_is_in_subset
