Preferred Label : Astragalus membranaceus/Angelica gigas/Trichosanthes kirilowii Maximowicz Mixed Herbal
Extract SH003;
NCIt synonyms : Am/Ag/Tk Herbal Extract SH003;
NCIt definition : A traditional Chinese medicine (TCM)-based herbal extract composed of Astragalus membranaceus
(Am), Angelica gigas (Ag) and Trichosanthes kirilowii Maximowicz (Tk), with potential
anti-angiogenic and antineoplastic activities. Upon administration, the active ingredients
in Am/Ag/Tk mixed herbal extract SH003 work synergistically to exert a number of activities
through various mechanisms of action (MOA); although, not all of the MOAs are fully
elucidated. SH003 blocks the binding of vascular endothelial growth factor (VEGF)
to its receptor VEGF receptor 2 (VEGFR2; KDR), thereby inhibiting VEGF/VEGFR2-mediated
signaling and VEGF-induced tumor endothelial cell migration, invasion and tube formation.
This inhibits tumor angiogenesis. In addition, SH003 inhibits signal transducer and
activator of transcription 3 (STAT3) activation and STAT3-mediated signaling, decreases
the production of the pro-inflammatory cytokine interleukin-6 (IL-6), and the expression
of STAT3 target genes. This induces apoptosis in, and reduces proliferation and metastasis
of, cancer cells in which STAT3 signaling is overactivated. STAT3 activation contributes
to inflammation in the cancer environment and tumor cell proliferation.;
Molecule name : SH003;
NCI Metathesaurus CUI : CL551052;
Origin ID : C148489;
UMLS CUI : C4725072;
Semantic type(s)
- concept_is_in_subset
