Preferred Label : Polyamine Transport Inhibitor AMXT-1501 Dicaprate;
NCIt synonyms : AMX 513 Dicaprate; AMXT-1501 Dicaprate; AMX513 Dicaprate; AMXT 1501 Dicaprate;
NCIt definition : The dicaprate salt form of AMXT-1501, an orally bioavailable polyamine transport inhibitor,
with immunostimulating and antineoplastic activities. Upon administration, AMXT-1501
targets, binds to and blocks polyamine transport from the bloodstream into the tumor
microenvironment (TME), thereby preventing cancer cell uptake. This decreases polyamine
concentrations inside the TME and tumor cell, inhibits tumor cell proliferation and
induces apoptosis. In addition, AMXT-1501 may abrogate polyamine-mediated immune suppression
in the TME. Polyamines, naturally found in normal, heathy cells, are required for
normal cell growth and division. In cancer cells, polyamines play key roles in tumor
cell proliferation and tumor-induced suppression of the patient's immune system.;
NCI Metathesaurus CUI : CL551058;
Origin ID : C148487;
UMLS CUI : C4725070;
Semantic type(s)
- concept_is_in_subset
