Preferred Label : Partially HLA-matched Adenovirus-specific T Lymphocytes;
NCIt synonyms : Partially HLA-matched Ad-specific CTLs; Partially HLA-matched Viralym-A Cells;
NCIt definition : A population of frozen, off-the-shelf, ready to administer, allogeneic, partially
or closely human leukocyte antigen (HLA) matched cytotoxic T-lymphocytes (CTLs) specifically
reactive to human adenovirus (Ad; AdV), with potential immunomodulating and anti-adenoviral
activities. Ex vivo, Ad-derived peptides were mixed with peripheral blood mononuclear
cells (PBMCs) from healthy donors and the Ad-reactive CTLs were selected, grown and
frozen. Upon thawing and infusion, the partially HLA-matched Ad-specific CTLs may
help reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections
after allogeneic stem cell transplant (HSCT) or in Ad-infected immunocompromised hosts.
This may induce killing of Ad-infected cells and may prevent or reduce severity of
Ad infection.;
NCI Metathesaurus CUI : CL550996;
Origin ID : C148419;
UMLS CUI : C4725019;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
