Preferred Label : FPV-Brachyury-TRICOM Vaccine;
NCIt synonyms : FPV-Brachyury Boost Vaccine; FPV-Brachyury;
NCIt definition : A cancer vaccine consisting of a recombinant fowlpox viral (FPV) vector encoding the
human transcription factor and tumor-associated antigen (TAA) brachyury, and a triad
of T-cell co-stimulatory molecules (TRICOM), which is comprised of the three human
immune-enhancing co-stimulatory molecules B7-1, ICAM-1 and LFA-3, with potential immunostimulatory
and antineoplastic activities. Upon subcutaneous administration occurring after the
administration of a proprietary modified vaccinia Ankara developed by Bavarian Nordic-based
prime vaccine (MVA-BN-brachyury), the booster vaccine FPV-brachyury vaccine potentiates
a cytotoxic T-lymphocyte (CTL) response against brachyury-expressing tumor cells.
The expression of brachyury, a member of the T-box family of transcription factors
that is overexpressed in numerous cancer cell types, is correlated with increased
epithelial-mesenchymal transition (EMT), cancer resistance, cancer progression and
metastasis. TRICOM enhances antigen-specific T-cell activation.;
NCI Metathesaurus CUI : CL551011;
Origin ID : C148402;
UMLS CUI : C4725009;
Semantic type(s)
- concept_is_in_subset
- has_target
