Preferred Label : MOF Compound RiMO-301;
NCIt definition : A nanoparticle-based metal-organic framework (MOF) compound composed of proprietary
X-ray-absorbing metals, with potential radiosensitizing properties. Upon intratumoral
administration and subsequent irradiation of the tumor site, RiMO-301 absorbs the
X-ray photons and produces reactive oxygen species (ROS), such as hydroxyl radicals
and singlet oxygen, which induces ROS-mediated DNA damage in the irradiated cancer
cells leading to tumor cell lysis. In addition, RiMO-301 may also contain an as of
yet unidentified immunomodulating agent loaded into the channels/pores of the construct
that may induce an immune response against the tumor-associated antigens (TAAs) released
by the lysed tumor cells, thereby locally killing additional tumor and non-tumor cells.
MOFs, porous crystalline materials composed of metal clusters and organic linkers,
generate ROS at much lower X-ray dosages than used in standard radiotherapy, which
results in reduced radiation exposure and X-ray damage to normal, healthy cells.;
Molecule name : RiMO-301;
NCI Metathesaurus CUI : CL550908;
Origin ID : C148280;
UMLS CUI : C4724955;
Semantic type(s)
- concept_is_in_subset
