Preferred Label : mRNA-based Personalized Cancer Vaccine NCI-4650;
NCIt synonyms : mRNA-based PCV NCI-4650;
NCIt definition : An mRNA-based therapeutic personalized cancer vaccine (PCV) targeting up to fifteen
tumor-associated antigens (TAAs) that are specifically expressed by a patient's cancer
cells, with potential immunostimulatory and antineoplastic activities. The cells from
the patient's tumor are analyzed and subjected to RNA sequencing to identify mutant
and immunogenic epitopes. The neoantigen epitopes are screened to select those that
induce a strong immune response in tumor- infiltrating lymphocytes (TILs) isolated
from the patient. The selected mRNA sequences encoding up to fifteen neoantigen epitopes
are incorporated in a proprietary formulation designed to maximize mRNA delivery and
minimize mRNA-triggered immune responses. Upon administration, the mRNA-based PCV
NCI-4650 is taken up and the mRNAs are translated by antigen presenting cells (APCs).
Then, the expressed epitopes are presented via major histocompatibility complex (MHC)
molecules on the surface of the APCs. This induces both cytotoxic T-lymphocyte (CTL)-
and memory T-cell-dependent immune responses that specifically target and destroy
the patient's cancer cells that express these neoantigens.;
Molecule name : NCI 4650; NCI-4650;
NCI Metathesaurus CUI : CL550832;
Origin ID : C148239;
UMLS CUI : C4724924;
Semantic type(s)
- concept_is_in_subset
