Preferred Label : Autologous AML/Dendritic Cell Fusion Vaccine;
NCIt synonyms : Autologous Dendritic Cell/AML Fusion Vaccine; Autologous DC/AML Fusion Vaccine; Autologous AML/DC Fusion Vaccine; DC/AML Fusion Cell Vaccine;
NCIt definition : A therapeutic cell-based cancer vaccine consisting of autologous dendritic cells (DCs)
fused with autologous acute myeloid leukemia (AML) cells, with potential immunostimulatory
and antineoplastic activities. The autologous AML/DC fusion vaccine is generated in
vitro by mixing DCs and irradiated AML cells harvested from individual patients, in
the presence of polyethylene glycol (PEG), to produce hybrid DC-leukemia fusion cells.
Upon re-administration, the autologous AML/DC fusion vaccine may elicit a cytotoxic
T-lymphocyte (CTL)-mediated antitumor immune response against a broad array of AML-associated
antigens, which may lead to AML cell lysis.;
NCI Metathesaurus CUI : CL550858;
Origin ID : C148214;
UMLS CUI : C4724903;
Semantic type(s)
- concept_is_in_subset
