Preferred Label : RIG-I selective Ligand RGT100;
NCIt definition : A synthetic RNA oligonucleotide and agonist of the retinoic acid-inducible gene I
protein (RIG-I; DDX58), with potential antineoplastic activity. Upon intratumoral/intralesional
administration, the RIG-I selective ligand RGT100 targets and binds to the cytosolic
RNA receptor RIG-I. This induces RIG-I-mediated signaling, upregulates interferon
(IFN)-alfa (IFN-a) and beta (IFN-b), and induces a potent IFN-mediated innate immune
response against the tumor cells. This induces the activation of natural killer (NK)
cells and cytotoxic T-lymphocytes (CTL) and induces apoptosis in cancer cells.;
Molecule name : RGT 100; RGT-100;
NCI Metathesaurus CUI : CL550880;
Origin ID : C148187;
UMLS CUI : C4724884;
Semantic type(s)
- concept_is_in_subset
