Preferred Label : TALEN-edited HPV16/18 E6/E7 Plasmid;
NCIt synonyms : TALEN-HPV16 E6/E7/TALEN-HPV18 E6/E7; TALEN-mediated HPV16/18 E6/7 Editing; Plasmid HPV16/18 E6E7-targeting TALEN; TALEN-HPV16 E6/E7/TALEN-HPV18 E6/E7 Plasmid;
NCIt definition : A transcription activator-like effector nuclease (TALEN)-edited plasmid targeting
human papillomavirus (HPV) types 16 (HPV16) and 18 (HPV18) epitopes E6 and E7, with
potential antineoplastic activity. Upon administration of TALEN-edited HPV16/18 E6/E7,
the TALEN targets and binds to specific sites on genomic HPV16 and 18 E6 and E7, and
cleaves the DNA sequences encoding E6 and E7. This causes double-strand DNA (dsDNA)
breaks, which prevents the transcription and translation of E6 and E7. In addition,
inhibition of HPV16/18 E6/E7 increases the expression of tumor suppressor genes, such
as p53 and retinoblastoma 1 (RB1). Altogether, TALEN-based HPV editing increases apoptosis
and inhibits tumor cell proliferation of HPV-driven cancer cells. HPV16/18 E6 and
E7 are oncogenes vital to viral function and carcinogenesis.;
NCI Metathesaurus CUI : CL550763;
Origin ID : C148186;
UMLS CUI : C4724883;
Semantic type(s)
- concept_is_in_subset
