Preferred Label : PD-1 knockout EBV-specific Cytotoxic T Lymphocytes;
NCIt synonyms : PD-1 knockout EBV-reactive CTLs; PD-1 knockout Epstein-Barr Virus-Cytotoxic T-lymphocytes; PD-1 knockout EBV-CTLs;
NCIt definition : A preparation of Epstein-Barr virus (EBV) reactive cytotoxic T-lymphocytes (CTLs)
in which the programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1) gene
is deleted, with potential immunomodulating activity. Upon administration of the PD-1
knockout EBV-specific CTLs, these CTLs target and induce selective toxicity in EBV-positive
cancer cells. This results in cell lysis and inhibition of cancer cell proliferation.
Expression of PD-1, an inhibitory receptor expressed on activated T-cells, plays a
key role in CTL suppression, T-cell exhaustion and CTL apoptosis. PD-1 knockout abrogates
T-cell exhaustion and increases T-cell activity and cytotoxicity. EBV, a ubiquitous
human herpesvirus, is associated with various cancer cell types.;
NCI Metathesaurus CUI : CL550768;
Origin ID : C148180;
UMLS CUI : C4724879;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
