Preferred Label : Licochalcone A;
NCIt synonyms : 2-Propen-1-one, 3-(5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-,
(E)-; 3-Dimethylallyl-4,4'-dihydroxy-6-methoxychalcone;
NCIt definition : A derivative of the phenol chalconoid, found in and extracted from the roots of Glycyrrhiza
species G. glabra and inflata, with potential anti-inflammatory, antibacterial, and
anticancer activities. Upon administration, licochalcone A inhibits the phosphatidylinositol-3-kinase/Akt/mammalian
target of rapamycin (PI3K/Akt/mTOR) signaling pathway and inhibits the activity of
c-Jun N-terminal kinase 1 (JNK-1), a member of the mitogen-activated protein kinase
(MAPK) family that plays a role in the MAPK-mediated signaling pathway. Inhibition
of the PI3K/Akt/mTOR- and MAPK-signaling pathways induces cell cycle arrest and apoptosis,
decreases migration and invasion of cancer cells, and inhibits tumor cell proliferation.
Licochalcone A also prevents the production of reactive oxygen species (ROS), and
reduces oxidative stress through the nuclear factor-erythroid 2-related factor 2 (Nrf2)
pathway.;
UNII : JTV5467968;
CAS number : 58749-22-7;
NCI Metathesaurus CUI : CL550765;
Origin ID : C148179;
UMLS CUI : C0125821;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
