Preferred Label : Oncolytic Vaccinia Virus TG6002;
NCIt synonyms : Oncolytic FCU1-expressing TK-RR-deleted Vaccinia Virus TG6002; Vaccinia Virus TG6002;
NCIt definition : A modified, replicative oncolytic vaccinia virus (VV), deleted of the genes for tyrosine
kinase (TK) and ribonucleotide reductase (RR), and expressing the yeast-originated,
bifunctional cytosine deaminase/uracil phosphoribosyltransferase gene (FCU1), with
potential immunomodulating and antineoplastic activities. Upon intravenous administration
of the oncolytic vaccinia virus TG6002, the virus preferentially targets and infects
tumor cells, causing oncolysis. In turn, the lysed tumor cells release various tumor-associated
antigens (TAAs), which induce an immune response against the tumor cells. Upon concomitant
administration of the non-cytotoxic prodrug flucytosine (5-fluorocytosine; 5-FC),
the FCU1 expressed in the infected cancer cells produce the enzymes cytosine deaminase
and uracil phosphoribosyltransferase which catalyze the conversion of 5-FC into the
cytotoxic forms 5-fluorouracil (5-FU) and 5-fluoro-uridilyl monophosphate (5-FUMP);
5-FU and 5-FUMP exert a cytotoxic effect in the infected tumor cells. Double gene
deletion (TK-RR-) restricts the propagation of TG6002 to the tumor cells, thereby
reducing toxicity to normal cells.;
Molecule name : TG 6002; TG-6002; T 601; T-601;
NCI Metathesaurus CUI : CL550766;
Origin ID : C148178;
UMLS CUI : C4724878;
Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
