" /> Anti-BCMA Antibody SEA-BCMA - CISMeF





Preferred Label : Anti-BCMA Antibody SEA-BCMA;

NCIt synonyms : Anti-BCMA Afucosylated Monoclonal Antibody SEA-BCMA;

NCIt related terms : SEA-BCMA;

NCIt definition : A humanized, afucosylated monoclonal antibody created using the proprietary, sugar-engineered antibody (SEA) platform and directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; TNFRSF17), with potential immunoadjuvant activity. Upon administration, the anti-BCMA antibody SEA-BCMA targets and binds to BCMA expressed on tumor cells. When administered with antibody-coupled T-cell receptor (ACTR)-expressing T-cells, the ACTR-expressing T-cells bind, with high affinity, to the anti-BCMA antibody SEA-BCMA. This activates the ACTR T-cells and the T-cells induce specific cytotoxic T-lymphocyte (CTL)-mediated cytotoxicity toward BCMA-expressing tumor cells. BCMA, a cell surface protein and member of the tumor necrosis factor (TNF) receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival.;

UNII : 3C28VJ95EV;

CAS number : 2115084-53-0;

Molecule name : SEA-BCMA;

NCI Metathesaurus CUI : CL550772;

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31/07/2025


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