Preferred Label : Trastuzumab Conjugate BI-CON-02;
NCIt definition : A conjugated form of trastuzumab, a humanized monoclonal antibody directed against
the human epidermal growth factor receptor 2 (HER2; ERBB2), with potential immunomodulating
and antineoplastic activities. Upon administration, the trastuzumab conjugate BI-CON-02
targets and binds to HER2 on the tumor cell surface, thereby inducing both cytotoxic
T-lymphocyte (CTL) and antibody-dependent cell-mediated cytotoxicity (ADCC) responses
against tumor cells that overexpress HER2. HER2, a tyrosine kinase receptor, is overexpressed
by many cancer cell types.;
Molecule name : BI-CON-02;
NCI Metathesaurus CUI : CL550783;
Origin ID : C148165;
UMLS CUI : C4724865;
Semantic type(s)
- concept_is_in_subset
