Preferred Label : Zirconium Zr 89 Anti-EGFR Monoclonal Antibody ABT-806;
NCIt synonyms : 89Zr-ABT806; 89Zr-labeled ABT-806;
NCIt definition : A radioimmunoconjugate composed of ABT-806, a humanized immunoglobulin G1 (IgG1) monoclonal
antibody directed against the epidermal growth factor receptor (EGFR), labeled with
the radioisotope zirconium Zr 89, with potential use as an imaging agent upon positron
emission tomography (PET). Upon administration of zirconium Zr 89 anti-EGFR monoclonal
antibody ABT-806, the antibody moiety binds to a specific EGFR epitope of either the
wild-type or the variant III mutant (EGFRvIII; de2-7 EGFR; DEGFR) on tumor cells.
Upon PET imaging, EGFR-expressing tumor cells can be visualized and assessed. This
may result in the quantification of EGFR-expressing tumor cells, an assessment of
the expected response to treatment with ABT-806 and the selection of patients that
would respond to ABT-806. ABT-806 is the humanized version of chimeric monoclonal
antibody 806. EGFR, a receptor tyrosine kinase overexpressed on the cell surfaces
of many tumor cell types, plays a key role in tumor cell proliferation.;
NCI Metathesaurus CUI : CL550781;
Origin ID : C148163;
UMLS CUI : C4724863;
Semantic type(s)
- concept_is_in_subset
