Preferred Label : Carbon C 14 Pevonedistat;
NCIt synonyms : [14 C]-pevonedistat; Carbon C 14-pevonedistat;
NCIt definition : An orally bioavailable radioconjugate composed of pevonedistat, a small molecule inhibitor
of NEDD8-activating enzyme (NAE), radiolabeled with the radioisotope carbon C 14,
with potential use for evaluating the pharmacokinetic profile of pevonedistat. Pevonedistat
binds to and inhibits NAE, which results in the inhibition of tumor cell proliferation
and survival. Labeling of pevonedistat with the radioactive tracer carbon C 14 allows
for the evaluation of pevonedistat's pharmacokinetic profile, including its absorption,
distribution, metabolism, and excretion (ADME).;
NCI Metathesaurus CUI : CL550787;
Origin ID : C148161;
UMLS CUI : C4724861;
Semantic type(s)
- concept_is_in_subset
