Preferred Label : Allogeneic TCR alpha/beta-positive T-lymphocyte-depleted Peripheral Blood Stem Cells;
NCIt synonyms : Allogeneic TCR alpha/beta T Cell-depleted PBSCs; Allogeneic TCR a/b T cell-depleted PBSCs;
NCIt definition : A preparation of allogeneic T-cell receptor (TCR) alpha/beta-positive T cell-depleted
peripheral blood stem cells (PBSCs), that can potentially be used for hematopoietic
stem cell transplantation (HSCT). Allogeneic PBMCs are processed, using the proprietary
CliniMACS device, to remove TCRalpha/beta T-cells, while retaining other cells, such
as donor-derived natural killer (NK) cells and gamma/delta T-cells. As TCR alpha/beta-positive
T-cells appear to be related to the development of graft versus host disease (GvHD),
depletion of these cells may lower the risk of the recipient developing GvHD. Upon
infusion of the TCR alpha/beta-positive T-cell-depleted PBSCs for allogeneic stem
cell transplantation (allo SCT), the alpha/beta-positive T-cell depletion as well
as the presence of allogeneic NK cells, and other cells, may facilitate engraftment,
exert graft-versus-leukemia effects, enhance post-transplant immune recovery, and
reduce the risk of infections and GvHD.;
NCI Metathesaurus CUI : CL550799;
Origin ID : C148149;
UMLS CUI : C4724851;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
