Preferred Label : Resiquimod Gel CD11301;
NCIt synonyms : CD11301 Topical Gel;
NCIt definition : A topical gel containing the Toll-like receptor (TLR) agonist resiquimod, an imidazoquinolinamine,
with potential immunomodulating activity. Upon topical application, the resiquimod
gel CD11301 binds to TLR7 and 8, which are found mainly on dendritic cells (DCs),
macrophages, and B-lymphocytes, and activates the TLR signaling pathway, which results
in the induction of the nuclear translocation of transcription activator nuclear factor
kappa-B (NF-kB) and activation of other transcription factors. Subsequently, NF-kB-dependent
gene expression is induced and cytokine production increases, especially interferon-alpha
(INF-a), which results in the enhancement of T-helper 1 (Th1) immune responses. In
addition, topical application of resiquimod appears to activate epidermal Langerhans
cells, leading to enhanced activation of T-lymphocytes.;
Molecule name : CD11301; CD 11301;
NCI Metathesaurus CUI : CL550801;
Origin ID : C148143;
UMLS CUI : C4724846;
Semantic type(s)
- concept_is_in_subset
