Preferred Label : Dextromethorphan/Bupropion Tablet AXS-05;
NCIt synonyms : DM BUP;
NCIt definition : A tablet composed of the non-opioid derivative of morphine dextromethorphan (DM) and
the aminoketone bupropion, with potential analgesic, antidepressant and anti-agitation
activities. Upon oral administration, the DM component may act as a weak N-methyl-D-aspartate
(NMDA) receptor antagonist, a sigma-1 receptor agonist and an inhibitor of the serotonin
and norepinephrine transporters, which together may alleviate pain, agitation, anxiety
and depression. While the bupropion component acts as a norepinephrine and dopamine
reuptake inhibitor and a central nicotinic acetylcholine receptor antagonist, which
is beneficial in the treatment of depression. Additionally, bupropion may increase
the bioavailability of DM, thus prolonging the therapeutic effects of DM.;
Molecule name : AXS-05; AXS 05;
NCI Metathesaurus CUI : CL545861;
Origin ID : C148102;
UMLS CUI : C4688375;
Semantic type(s)
- concept_is_in_subset
