Preferred Label : HSATII DNA;
NCIt synonyms : Human Satellite II Repeat DNA; HSAT-II DNA;
NCIt definition : Human HSATII is comprised of an approximately 26 bp tandem repeat sequence that is
the main component of pericentromeric heterochromatin located on chromosomes 2, 5,
7, 10, 13, 14, 15, 17, 21, 22, and Y; additionally large (5-6 Mb) blocks of this repeat
are located at 1q12 and on chromosome 16. This satellite DNA is not expressed in normal
cells. Aberrant expression and translation of HSATII RNA, which occurs when the sequence
is demethylated, is associated with various cancers and may result in sequestration
of transcription regulation proteins.;
NCI Metathesaurus CUI : CL545889;
Origin ID : C148069;
UMLS CUI : C4553906;
Semantic type(s)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_found_in_organism
