Endothelin-3 - CISMeF

Preferred Label : Endothelin-3;

NCIt synonyms : Preproendothelin 3; Preproendothelin-3; Endothelin 3; EDN3; ET-3; PPET3;

NCIt definition : Endothelin-3 (238 aa, 26 kDa) is encoded by the human EDN3 gene. This protein is involved in vasoconstriction.;

NCIt note : Endothelin-3 is proteolytically processed N-terminally by prohormone convertases and C-terminally by Kell blood group glycoprotein to release the biologically active form of endothelin-3, which is composed of amino acids 97-117 of the proprotein and is a ligand for endothelin B receptor (EDNRB).;

Details

Origin ID

C148000;

UMLS CUI

C3852391;

Automatic exact mappings (from CISMeF team)
- Endothelin 3 [OMIM gene]
- Endothelin-3 [MeSH Descriptor]
- preproendothelin-3 [MeSH Supplementary Concept]
- preproendothelin-3 [MeSH concept]
OMIM relation
- Endothelin 3 [OMIM gene]
See also inter- (CISMeF)
- endothelin 3 [ORDO Gene]
- endothelin 3 [HGNC gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
UMLS correspondences (same concept)
- EDN3 protein, human [MeSH Supplementary Concept]
- EDN3 protein, human [MeSH concept]
gene_encodes_gene_product
- EDN3 Gene [NCIt concept]
- Peptide Hormone Gene [NCIt concept]
gene_product_expressed_in_tissue
- Endothelium [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Endothelin Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Muscle Contraction [NCIt concept]
- Stimulation of Cell Proliferation [NCIt concept]

Keyword's position in hierarchy(ies) :

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