NCIt definition : A proprietary humanized monoclonal antibody against human sodium-dependent phosphate
transport protein 2B (SLC34A2; NaPi2b), with potential antineoplastic activity. Upon
administration of upinitatug, the antibody targets and binds to NaPi2b expressed on
tumor cells. Although the tumor cell killing effects of upinitatug are not established,
this binding may induce an antibody-dependent cellular cytotoxicity (ADCC)-mediated
immune response against NaPi2b-expressing tumor cells, and/or may inhibit NaPi2b-mediated
sodium and phosphate ion cotransport activity and ion-dependent tumor cell signaling.
NaPi2b, a tumor-associated antigen (TAA), is overexpressed on a variety of tumor cells.
It plays a key role in the transport of inorganic phosphate (Pi) and the maintenance
of phosphate homeostasis.;
Semantic type(s)