Recombinant Soluble T4

Preferred Label : Recombinant Soluble T4;

NCIt definition : A recombinant form of CD4 antigen with anti-HIV application. Recombinant soluble T4 antigen (rsT4) is derived from cell surface antigen CD4 lacking its transmembrane and cytoplasmic domains, thereby the agent is mobile within tissues. rsT4 binds to the envelope glycoprotein gp110 of HIV and prevents the binding of virus to CD4 positive lymphocytes, resulting in an inhibition of virus infectivity.;

Details

Origin ID

C1473;

UMLS CUI

C0210233;

Currated CISMeF NLP mapping
- recombinant soluble CD4 [MeSH Supplementary Concept]
- recombinant soluble CD4 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- recombinant soluble CD4 [MeSH concept]
- recombinant soluble CD4 [MeSH Supplementary Concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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