Preferred Label : Allogeneic Double Negative T Cells;
NCIt synonyms : Allogeneic DNT Cells;
NCIt definition : A population of healthy, donor-derived CD4 and CD8 double-negative T-lymphocytes (DNTs),
with potential immunomodulating and anti-leukemic activities. The DNTs are expanded
ex vivo in order to enhance their tumor destroying potential. Upon administration
of the allogeneic DNTs (DNT-UHN-1), the receptors NKG2-D type II integral membrane
protein (KLRK1; NKG2D) and DNAX accessory molecule 1 (cluster of differentiation 226;
CD226; DNAM-1) expressed on the DNTs recognize and bind to their cognate ligands expressed
on leukemia cells. Upon binding, the DNTs release interferon-gamma (IFN-g), thereby
destroying the tumor cells. DNTs derived from peripheral blood of healthy donors appear
to be effective against certain types of tumor cells, including leukemia cells, and
do not attack normal hematopoietic cells. NKG2D, a member of the CD94/NKG2 family
of C-type lectin-like receptors, and DNAM-1, a member of the immunoglobulin superfamily
containing 2 Ig-like domains of the V-set, play a key role in natural killer cell
(NK)-mediated tumor cell killing. Certain tumor cells express higher levels of NKG2D
and DNAM-1 ligands on their surfaces, thereby increasing their susceptibility to DNT-mediated
cell lysis.;
Molecule name : DNT-UHN-1;
NCI Metathesaurus CUI : CL545065;
Origin ID : C147134;
UMLS CUI : C4687728;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
