" /> Pavurutamab - CISMeF





Preferred Label : Pavurutamab;

NCIt synonyms : Anti-BCMA x Anti-CD3 BiTE AMG 701; BiTE Antibody AMG 701; Bispecific T-cell Engager Antibody AMG 701; BCMA/CD3-directed Bispecific T-cell Engager Antibody AMG 701; Anti-BCMA/CD3 BiTE Antibody AMG 701;

NCIt definition : A bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; TNFRSF17), fused to one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of pavurutamab, this bispecific antibody binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA found on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, which results in the CTL-mediated cell death of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival.;

UNII : GLR3JG8TZU;

CAS number : 2250292-39-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2250292-39-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AMG-701; AMG 701;

NCI Metathesaurus CUI : CL545027;

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12/05/2024


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