Preferred Label : Anti-DLL3/CD3 BiTE Antibody AMG 757;
Obsolete resource : true;
NCIt synonyms : Anti-DLL3 x Anti-CD3 BiTE AMG 757; BiTE Antibody AMG 757; DLL3/CD3-directed Bispecific T-cell Engager Antibody AMG 757; Bispecific T-cell Engager Antibody AMG 757;
NCIt definition : A bispecific T-cell engager (BiTE) antibody composed of two single-chain variable
fragments (scFv), one directed against the tumor-associated antigen (TAA) delta-like
protein 3 (DLL3) fused to one that is directed against the CD3 antigen found on T-lymphocytes,
with potential immunostimulating and antineoplastic activities. Upon administration
of anti-DLL3/CD3 BiTE antibody AMG 757, this bispecific antibody binds to both the
CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the DLL3 antigen found on DLL3-expressing
tumor cells. This activates and redirects CTLs to DLL3-expressing tumor cells, which
results in the CTL-mediated cell death of DLL3-expressing tumor cells. DLL3, a Notch
pathway protein, is overexpressed on a variety of cancer cell types. It plays a key
role in embryonic development and in tumor initiation and proliferation.;
NCIt note : See 'Tarlatamab(C175858)';
Concept status : Retired_Concept;
Molecule name : AMG-757; AMG 757;
NCI Metathesaurus CUI : CL545042;
Origin ID : C147027;
UMLS CUI : C4687660;
Semantic type(s)
- UMLS correspondences (same concept)
- AMG 757 [MeSH Supplementary Concept]
