Loxoribine - CISMeF

Preferred Label : Loxoribine;

NCIt synonyms : 7-Allyl-8-oxoguanosine;

NCIt definition : A guanine ribonucleotide derivative with immunostimulatory and immunomodulatory activity. Loxoribine undergoes facilitated transport across the plasma membrane into the cytoplasmic compartment of the cell and acts intracellularly, bypassing the biochemical steps involved in the membrane signal transduction pathway used by Ag or anti-IgM Abs to activate B cells. This agent activates the Toll-like receptor 7 (TLR7), a member of the TLR family of pathogen-associated molecular pattern recognition receptors thereby activating the innate immune system. This activation requires endosomal maturation and recognition is restricted to TLR7. As a result, loxoribine induces cycling B cells to proliferate and differentiate non-specifically and recruit antigen-reactive B cells to undergo differentiation to antibody production, markedly amplifying the underlying response in the process.;

UNII : 9CAS0V66OI;

InChIKey : VDCRFBBZFHHYGT-IOSLPCCCSA-N;

CAS number : 121288-39-9;

Chemical formula : C13H17N5O6;

Details

Origin ID

C1470;

UMLS CUI

C0209660;

Currated CISMeF NLP mapping
- loxoribine [MeSH concept]
- loxoribine [MeSH Supplementary Concept]
Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- loxoribine [MeSH Supplementary Concept]
- loxoribine [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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