NCIt definition : An orally bioavailable inhibitor of the membrane-bound O-acyltransferase (MBOAT) porcupine
(PORCN), with potential antineoplastic, protective and regenerative activities. Upon
oral administration, PORCN inhibitor CGX1321 specifically targets and binds to PORCN
in the endoplasmic reticulum (ER), thereby inhibiting the post-translational palmitoylation
and secretion of Wnt ligands, thus preventing the activation of Wnt-mediated signaling,
and inhibiting cell growth in Wnt-driven tumors. In addition, by inhibiting the secretion
of Wnt ligands and preventing Wnt-mediated signaling, CGX1321 may also limit fibrosis
and promote regeneration of certain tissues upon cell injury. PORCN catalyzes the
palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion. Wnt signaling
is dysregulated in a variety of cancers and plays a key role in tumor cell proliferation.
It also plays a key role in tissue regeneration.;
Semantic type(s)