Preferred Label : Etevritamab;
NCIt synonyms : Bispecific BITE Antibody AMG 596; BiTE Antibody AMG 596; Anti-EGFRvIII x Anti-CD3 Bi-specific T-cell Engager AMG 596; EGFRvIII specific BiTE Antibody AMG 596; Anti-EGFRvIII/CD3 BiTE Antibody AMG 596;
NCIt definition : A proprietary recombinant bispecific T-cell engager (BiTE) antibody composed of two
single-chain variable fragments (scFv), one that is directed against a tumor-associated
antigen (TAA), the epidermal growth factor receptor (EGFR) deletion-mutant form, EGFR
variant III (EGFRvIII), and one that is directed against the CD3 antigen found on
T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon
administration of etevritamab, the bispecific antibody binds to both the CD3 antigen
on cytotoxic T-lymphocytes (CTLs) and EGFRvIII found on EGFRvIII-expressing tumor
cells. This activates and crosslinks CTLs with EGFRvIII-expressing tumor cells, which
results in the CTL-mediated cell death of EGFRvIII-expressing tumor cells. EGFRvIII,
a mutation in the EGFR gene where exons 2-7 have been deleted, is overexpressed by
a variety of cancers, but is absent in normal, healthy cells. It plays a key role
in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and
chemotherapy.;
UNII : WR4J8FV2SM;
CAS number : 2329692-74-0;
Molecule name : AMG 596; AMG-596;
NCI Metathesaurus CUI : CL544854;
Origin ID : C146824;
UMLS CUI : C5446319;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
