Preferred Label : Intismeran Autogene;
NCIt synonyms : mRNA-based PCV mRNA-4157; PCV mRNA-4157; mRNA-based Personalized Cancer Vaccine mRNA-4157;
NCIt definition : An mRNA-based individualized, therapeutic personalized cancer vaccine (PCV) targeting
twenty tumor-associated antigens (TAAs) that are specifically expressed by the patient's
cancer cells, with potential immunostimulatory and antineoplastic activities. The
cells from the patient's tumor are analyzed, and genetic sequencing is used to identify
twenty neoantigen epitopes that may elicit the strongest immune response in the patient.
The sequences encoding the twenty patient-specific epitopes are transcribed and loaded
onto a single mRNA molecule. Upon administration, intismeran autogene is taken up
and translated by antigen presenting cells (APCs). Then, the expressed epitopes are
presented via major histocompatibility complex (MHC) molecules on the surface of the
APCs. This leads to an induction of both cytotoxic T-lymphocyte (CTL)- and memory
T-cell-dependent immune responses that specifically target and destroy the patient's
cancer cells that express these neoantigens.;
UNII : ZG6U44T8SG;
CAS number : 2931460-85-2;
Molecule name : mRNA-4157; mRNA 4157; V-940; V 940;
NCI Metathesaurus CUI : CL544754;
Origin ID : C146813;
UMLS CUI : C4687472;
Semantic type(s)
- concept_is_in_subset
