Preferred Label : mRNA-based Personalized Cancer Vaccine mRNA-4157;
NCIt synonyms : mRNA-based PCV mRNA-4157; PCV mRNA-4157;
NCIt definition : An mRNA-based individualized, therapeutic personalized cancer vaccine (PCV) targeting
twenty tumor-associated antigens (TAAs) that are specifically expressed by the patient's
cancer cells, with potential immunostimulatory and antineoplastic activities. The
cells from the patient's tumor are analyzed, and genetic sequencing is used to identify
twenty neoantigen epitopes that may elicit the strongest immune response in the patient.
The sequences encoding the twenty patient-specific epitopes are transcribed and loaded
onto a single mRNA molecule. Upon administration, the mRNA-based PCV mRNA-4157 is
taken up and translated by antigen presenting cells (APCs). Then, the expressed epitopes
are presented via major histocompatibility complex (MHC) molecules on the surface
of the APCs. This leads to an induction of both cytotoxic T-lymphocyte (CTL)- and
memory T-cell-dependent immune responses that specifically target and destroy the
patient's cancer cells that express these neoantigens.;
Molecule name : mRNA-4157; mRNA 4157; V-940; V 940;
NCI Metathesaurus CUI : CL544754;
Origin ID : C146813;
UMLS CUI : C4687472;
Semantic type(s)
- concept_is_in_subset
