Preferred Label : Allogeneic GM-CSF-secreting Breast Cancer Vaccine SV-BR-1-GM;
NCIt synonyms : Breast Cancer Vaccine SV-BR-1-GM; SV-BR-1 Breast Cancer Cell Line Vaccine; GM-CSF Gene-transfected Breast Cancer Vaccine SV-BR-1-GM; SV-BR-1-GM Vaccine;
NCIt definition : A vaccine consisting of irradiated allogeneic breast cancer cells, derived from the
breast cancer cell line SV-BR-1 that are transfected with the immunostimulant granulocyte-macrophage
colony-stimulating factor (GM-CSF; CSF2) gene, with potential immunostimulating and
antineoplastic activities. Upon intradermal administration of the allogeneic GM-CSF-secreting
breast cancer vaccine SV-BR-1-GM, the genetically-modified cells secrete GM-CSF. This
potentiates a tumor-specific cytotoxic T-lymphocyte (CTL) immune response against
breast cancer cells.;
Drug name : Bria-IMT;
Molecule name : SV-BR-1-GM;
NCI Metathesaurus CUI : CL544722;
Origin ID : C146711;
UMLS CUI : C4687432;
Semantic type(s)
- concept_is_in_subset
