Preferred Label : Fluorine F 18 Tetrafluoroborate;
NCIt synonyms : 18F-Tetrafluoroborate; 18F-TFB;
NCIt definition : A radioconjugate composed of the sodium-iodide symporter (NIS; SLC5A5) ligand tetrafluoroborate
(TFB) labeled with the radionuclide fluorine F 18, with potential use as an imaging
agent for NIS-expressing cells upon positron emission tomography (PET). Upon administration,
fluorine F 18 tetrafluoroborate targets, binds to, and is taken up by NIS, which is
expressed on the surface of cells in the normal thyroid gland, lactating mammary gland
and various tumors. Then, NIS-expressing cells can be visualized and NIS expression
levels can be assessed using PET. Since iodides are taken up by NIS, this agent may
predict the uptake of radioactive iodine by thyroid cancer cells.;
NCI Metathesaurus CUI : CL544735;
Origin ID : C146693;
UMLS CUI : C4687425;
Semantic type(s)
- concept_is_in_subset
- has_target
