Sorivudine - CISMeF

Preferred Label : Sorivudine;

NCIt synonyms : 5-Bromovinyl-araU; BV-araU; 2,4(1H,3H)-pyrimidinedione, 1-beta-D-arabinofuranosyl-5-(2-bromoethenyl); 1-Beta-D-arabinofuranosyl-(E)-5-(2-bromovinyl)uracil; 5-(2-bromovinyl)-1-beta-D- arabinofuranosyluracil; ( )-1-Beta-D-arabinofuranosyl-5-[(E)-2-bromovi- ny1] uracil; (E)-1-beta-D-arabinofuranosyl-5-(2-bromoethenyl)-2,4(1H,3H)-pyrimidinedione;

NCIt definition : A synthetic thymidine analogue with potent antiviral activity against herpes simplex and varicella zoster viruses. Sorivudine is phosphorylated into triphosphate form within the cells; this metabolite interferes with viral DNA replication by inhibiting DNA polymerase activity without been incorporated into elongating viral DNA. Due to the dangerous effects of drug-drug interactions via its metabolite, sorivudine has been removed from the market.;

Alternative definition : NCI-GLOSS: An antiviral drug that is being studied as a treatment for herpesvirus. It belongs to the family of drugs called nucleic acid synthesis inhibitors.;

UNII : C7VOZ162LV;

CAS number : 77181-69-2;

Drug name : Bravavir; Usevir;

Molecule name : SQ 32756; YN-72;

Chemical formula : C11H13BrN2O6;

Codes from synonyms : CDR0000335515;

Details

Origin ID

C1460;

UMLS CUI

C0207628;

Currated CISMeF NLP mapping
- sorivudine [MeSH concept]
- sorivudine [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- sorivudine [MeSH concept]
- sorivudine [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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