Liatermin - CISMeF

Preferred Label : Liatermin;

NCIt synonyms : Glial Cell-Line Derived Neurotrophic Factor; GDNF; Recombinant Glial Cell-Line Derived Neurotrophic Factor;

NCIt definition : A recombinant therapeutic agent which is chemically identical to or similar to endogenous glial cell line-derived neurotrophic factor (GDNF). GDNF is a glycosylated, disulfide-bonded homodimer distantly related member of the transforming growth factor-beta superfamily. This agent is important in the development and maintenance of dopamine neurons, has restorative effects in a wide variety of rodent and primate models of Parkinson disease, and may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons. (NCI04);

UNII : PI2EOQ4KE3;

CAS number : 188630-14-0;

Details

Origin ID

C1459;

UMLS CUI

C1527004;

Automatic exact mappings (from CISMeF team)
- Glial cell line-derived neurotrophic factor [OMIM gene]
- glial cell derived neurotrophic factor [ORDO Gene]
- glial cell line-derived neurotrophic factor [OBI concept]
Currated CISMeF NLP mapping
- glial cell Line-Derived neurotrophic factor [MeSH concept]
- glial cell Line-Derived neurotrophic factors [MeSH concept]
- glial cell line-derived neurotrophic factor [MeSH Descriptor]
- glial cell line-derived neurotrophic factors [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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