Preferred Label : Morpholinodoxorubicin;
NCIt synonyms : morpholino-ADR; morpholino-adriamycin; 5,12-Naphthacenedione, 7, 8, 9, 10-tetrahydro-6, 8, 11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,
3, 6-trideoxy-3-(4-morpholinyl)-alpha-L-lyxo-hexopyranosyl] oxy]-, hydrochloride,
(8S-cis)-;
NCIt definition : A semisynthetic derivative of the anthracycline antineoplastic antibiotic doxorubicin.
As an antineoplastic agent, morpholinodoxorubicin is more potent than doxorubicin.
Similar to doxorubicin, morpholinodoxorubicin intercalates into DNA and causes single-
and double-strand breaks in DNA via inhibition of topoisomerase I and II. Unlike doxorubicin,
this agent is metabolized in vivo to a DNA-alkylating derivative that forms DNA interstrand
cross-links, thereby potentiating its doxorubicin-like cytotoxicity. (NCI04);
UNII : X0N4EFN4AI;
CAS number : 89196-04-3;
NSC code : 354646;
Origin ID : C1442;
UMLS CUI : C0173377;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
